Arsenostibino compounds and process of making same.



omen sTAirEs .gnlrnntr OFFICE.

39. UL-EHELICH AND PAUL KARBER, OF FRANKFORT-ON-THE-MAIN, GER IFIANY, ASSIGNORS T FARBW'ERKE VORM. MEISTER LUCIUS & BRUNING, 015 3OCHST- ON-THE-IVIAIN, GERMANY, A. CORPORATION OF GERMAN Y..

ARSENOSTIBINO COMPOUNDS AND PROCESS OF MAKING SAME.

icense.

No Drawing.

To all whom may concern;

Be it known that we, PAUL EnRLIcn, hi. 1)., professor of medicine, and PAUL linuuau, Ph. 1)., chemist, citizens of the Empire of Germany and the Republic of Switzerland, respectively, residing at Frankfort on-the-h'lain, Germany, haveinvented' certain. ne and useful Improvements in Arsenostibino Compounds and Processes of l'laking Same, of which the following is a specification.

We have found that by treating aromatic primary arsins with halogen-antimony compounds oi the formula: HlmSbX wherein X stands for a monovalent inorganic or organic residue, new compounds are obtained, to which the constitution: (aromatic residue)-As: bX may be attributed and u 'ich may be termed arsenostibino compounds. They are of therapeutical value in These arsenic antimony compounds are yellow to dark brown amorphousbodies, easily oxidizable and forming salts which are readily soluble in water and in diluted hydrochloric acid. They havea strong reducing action, for instance upon Fehlings solution, or

upon an ammoniacal solution of silver nitrate. The following example illustrates our invention: A methyl alcoholic solution of 90 grams of 3-amino-4oxyphenylarsin acidulated with hydrochloric'acid' is n'rlded to a solution of 29 grams of monophedelgtibmedichlorid C E- Still in methyl afaohol.

The color of this mixture turns intensely brownish-red. The liquid is run into a large quantity of ether whereupon the condensation product of the formula NHzHCl is precipitated as a yellowish-brown, fiahy precipitate. The new body thus obtained is Specification of Letters Patent;

Patented Aug. 25, 196M;

Application filed July 30, 1913. Serial No. 782,014.

readily soluble in Water, alkalis, diluted hydrochloric acid, glycerin, glycol and the like.

Having now described our invention. what we claim is:

1. The process of preparing arseno bino compounds of the constitutional formula: (aromatic residue) -As=SbX which consists in causing halogenantimonycompounds I of the formula HlggSbX, wherein X stands for monovalentresidue, to act upon aromatic primary arsins.

2. As new products, salts with acids of arseno-stibino compounds of the general formula: (aromatic' residue)1is:SbX wherein X stands for a monovalent residue and the aromatic residue contains a salt- ,i orming atom group, said salts being amorphous yellowish-brown to brown powders which have a strongly reducing action in an ammoniacal solution of silver nitrate, being readily soluble in water and diluted hydro: chloric arid, but diflicultly soluble in ether and benzene.

As a new product, the hydrochloric acid salt of the arseno-stibino compound of the constitutional formula Vitnesses:

J EAN GRUND, CARL GRUND. 

